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Derek Murphy, PhD

DerekMurphy_resized

Contact

Telephone
01 8057700
Location
Room 8, St Patrick's

Section

Lecturer in Biology and Chemistry, Trinity International Foundation Programme

 

Qualifications

B.A. (Mod) in Genetics (TCD)

Ph.D. in Developmental Genetics (Trinity College Dublin and Georg-August-Universität Göttingen)

 

Teaching/Lecturing

Lecturer/Tutor for Biology and Chemistry for the International Foundation Programme for TCD and UCD, based at the Dublin International Study Centre (2012-2018).

Lecturer for Physiology and Molecular Biology, School of Biological Sciences, Dublin Institute of Technology (2009-2013)

Lecturer for Translational Medicine and Biomarkers (annual module), Postgraduate Medical School, University of Surrey

Lecturer, Dept. of Physiology, Royal College of Surgeons in Ireland (2003-2009)

 

Research

Associate Director of Centre for Human Proteomics, RCSI (2005-2009)

Senior Scientist at the Centre for Human Proteomics, RCSI (2002-2005)

Postdoctoral researcher in the “Protein Technology Group”, Max-Planck Institute for Molecular Genetics, Berlin (2001-2002)

Postdoctoral researcher at the Medizinische Klinik mit Schwerpunkt Hepatologie/Gastroenterologie, Charité, Humboldt Universität, Berlin (1998-2001)

Postdoctoral researcher in the Institut für Humangenetik und medizinische Biologie in Halle, Germany (1997-1998)

 

Publications

Wong KK, Gascoyne DM, Brown PJ, Soilleux EJ, Snell C, Chen H, Lyne L, Lawrie CH, Gascoyne RD, Pedersen LM, Møller MB, Pulford K, Murphy D, Green TM, Banham AH (2014). “Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients.” Leukemia Feb;28(2), 362-372.

Patel S, Murphy D [joint first author], Haralambieva E, Abdulla ZA, Wong KK, Chen H, Gould E, Roncador G, Hatton CSR, Anderson AP, Banham AH, Pulford K (2014). “Increased expression of phosphorylated FADD in anaplastic large cell and other T-cell lymphomas.” Biomarker insights 77-84.

Patel S, Chen H, Monti L, Gould E, Haralambieva E, Schmid J, Toomey D, Woessmann W, Roncador G, Hatton CSR, Liggins AP, Taramelli R, Banham AH, Acquati F, Pulford K and Murphy D. [joint last author] (2012). “RNASET2–an autoantigen in anaplastic large cell lymphoma identified by protein array analysis.” Journal of Proteomics Sept;75(17), 5279-5292

Meehan M, Parthasarathi L, Moran N, Jefferies C, Foley N, Lazzari E, Murphy D, Ryan J, Chan TA and Stallings RL (2012) “Protein Tyrosine Phosphatase Receptor Delta (PTPRD) Acts as a Neuroblastoma Tumor Suppressor by Destabilizing the Aurora Kinase A Oncogene.” Molecular Cancer Sept;11(6).

Arthur JF, Shen Y, Gardiner EE, Coleman L, Murphy D, Kenny D, Andrews RK, Berndt MC (2011). “TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets.” J Thromb Haemost. Jan;9(1):163-72. (Corrigendum: Dec 2011)

Dervan EW, Chen H, Ho SL, Brummel N, Schmid J, Toomey D, Haralambova M, Gould E, Wallace DM, Prehn JH, O'Brien C, Murphy D (2010). “Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma.” Invest Ophthalmol Vis Sci. Jun;51(6):2968-75.

Raab M, Daxecker H, Edwards RJ, Treumann A, Murphy D, Moran D [joint last author] (2010). “Protein interactions with the platelet integrin  IIb regulatory motif.” Proteomics Aug;10(15):2790-800.

Murphy D, Parker J, Zhou M, Karsan A, Fadlelmola F, Steidl C, Gascoyne RD, Chen H, Banerjee D (2010). “Expression of Cytochrome b5b (CYB5B) in Hodgkin Lymphoma and Aggressive Non-Hodgkin Lymphomas; a Potential Therapeutic Target.” Molecular Cancer Jan 26;9(1):14.

Kijanka G, Hector S, Kay E, Murray F, Cummins R, Murphy D, MacCraith BD, Prehn J, Kenny D (2010). “Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer.” Gut. Jan 59(1):69-78.

Kijanka G, Barry R, Cordell J, Chen H, Gould E, Seidlits SK, Schmid J, Morgan M, Mason DY†, Murphy D (2009). “Defining the molecular target of a ‘paraffin-reactive’ antibody derived from a lymphoma cell line using recombinant protein arrays.” Anal Biochem. Dec 15;395(2):119-24.

Gregor Kijanka and Derek Murphy (2009). “Protein arrays as discovery tools in oncology.” Journal of Proteomics. Aug 20;72(6):936-44.

Kijanka G, IpCho S, Baars S, Chen H, Hadley K, Beveridge A, Gould E, Murphy D (2009). “Rapid characterization of binding specificity and cross-reactivity of antibodies using recombinant human protein arrays.” Journal of Immunological Methods. 340(2):132-7.

Larkin D, Treumann A, Murphy D, DeChaumont C, Kiernan A and Moran N (2008). “Compartmentalization regulates the interaction between the platelet integrin alphaIIbbeta3 and ICln.” British Journal of Haematology, 144(4):580-90.

Horn S, Lueking A, Murphy D, Staudt S, Gutjahr C, Schulte K, König A, Landsberger M, Lehrach H, Felix SB, Cahill DJ (2006). “Profiling humoral auto-immune repertoire of dilated cardiomyopathy (DCM) patients and development of a disease-associated protein chip.” Proteomics 6(2): 605-613.

Murphy D, Cahill DJ (2005). “Protein Arrays.” Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. ISBN: 0-470-84974-6.

Gutjahr C, Murphy D, Lueking A, Koenig A, Janitz M, O’Brien J, Korn B, Horn S, Lehrach H, Cahill DJ (2005). “High-density mouse protein array from a TH1 cell cDNA library.” Genomics. 85 285–296

Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N (2004). “ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation.” J Biol Chem. 279(26):27286-93.

Murphy D, Detjen KM, Welzel M, Farwig K, Wiedenmann B, Rosewicz S (2003). “Downregulation of p21waf/cip-1 mediates apotosis of human hepatocellular carcinoma cells in response to interferon-gamma.” Exp. Cell. Res. 282(2): 78-89.

Angenendt P, Glokler J, Murphy D, Lehrach H, Cahill DJ (2002). “Toward optimized antibody microarrays: a comparison of current microarray support materials.” Anal. Biochem., 309(2): 253-60.

Murphy D, Detjen KM, Welzel M, Wiedenmann B, Rosewicz S (2001). “Interferon-alpha delays S-phase progression in human hepatocellular carcinoma cells via inhibition of specific cyclin-dependent kinases.” Hepatology, 33(2): 346-356.

Plath T, Detjen K, Welzel M, von Marschall Z, Murphy D, Schirner M, Wiedenmann B, Rosewicz S (2000). “A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor.” J. Cell Biol., 150(6): 1467-78.

Murphy D, Seemann S, Wiese S, Kirschner R, Grzeschik KH, Thies U (1997). “The genomic structure and pattern of expression of the human gene FKHL13 and its mouse homologue hfh-4, members of the HNF-3/fork head gene family.” Genomics, 40: 462-469.

Wiese S, Emmerich D, Schröder B, Murphy DB, Grzeschik KH, Geurts Kessel A, Thies U (1997). “The novel human HNF-3/fork head like 5 (HFKHL5) gene: chromosomal localisation and expression pattern.” DNA and Cell Biology, 16(2): 165-171.

Engel W, Murphy D, Schmid M (1996). “Are there genetic risks associated with microassisted reproduction?” Human Reproduction, 11: 2359-2370.

Aho H, Schwemmer M, Tessmann D, Murphy D, Mattei M-G, Engel W, Adham IM (1996). “Isolation, expression and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP).” Genomics, 32: 184-190.

Adham IM,  Tessmann D, Soliman KA, Murphy D, Sander C, Engel W (1996). “Cloning, expression, and chromosomal localization of the rat mitochondrial capsule selenoprotein gene (MCS): the reading frame does not contain potential UGA selenocysteine codons.” DNA and Cell Biology, 15: 159-166.

Wiese S, Murphy DB, Schlung A, Burfeind P, Schmundt D, Schnülle V, Mattei M-G, Thies U (1995). “Human brain factor 2 is a member of the fork head gene family and is linked to the human brain factor 1 gene on chromosome 14q.” Biochim. Biophys. Acta, 1262: 105-112.

Burkhardt E, Adham IM, Hobohm U, Murphy D, Sander C, Engel W (1994). “A human cDNA clone for the Leydig insulin-like peptide (Ley I-L).” Human Genetics, 94: 91-94.

Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei M-G, Schulz-Schaeffer W, Thies U (1994). “Human brain factor 1, a new member of the fork head gene family.” Genomics, 21: 551-557.

 

Research Webpage:       https://www.researchgate.net/profile/Derek_Murphy