Derek Murphy PhD

Rannóg

Department of Global Diversity, Sustainability & Intercultural Education

Role

Lecturer

Biography

Derek Murphy graduated from Trinity College Dublin with a B.A. (Mod) in Genetics in 1990. His PhD in the areas of developmental genetics and biochemistry entitled “Studies of the fork head gene family in mammals” was awarded in 1997 also by Trinity College, with the experimental work carried out at the Institüt für Humangentik in the Georg-August-Universität Göttingen, Germany. As a postdoctoral researcher in Germany, Derek worked in the area of cancer biology, studying the effects of various drugs on growth rates of cancer cell lines, before moving into the field of high-throughput protein array applications, including identification of disease markers in autoimmune disorders. Returning to Ireland in 2003, Derek’s research continued to focus on applications of protein array technology, with a focus on discovery of novel biomarkers in cancer (lymphoma) and glaucoma. Throughout Derek’s research career he maintained a keen interest in teaching, both lecturing and laboratory-based. While at DIT from 2009-2013, Derek lectured and led teaching practicals in molecular biology and physiology. Derek has been teaching international students for more then 10 years. In 2012, he began teaching at Foundation level to prospective students for Trinity College and University College Dublin. Now based in Marino Institute of Education, with a dedicated teaching laboratory, Derek dedicates himself primarily to teaching chemistry and biology to students aiming to study medical and biological sciences, engineering and computer science.

Qualifications

Ph.D. in Developmental Genetics (Trinity College Dublin and Georg-August-Universität Göttingen)

B.A. (Mod) in Genetics (TCD)

Teaching

ORCID ID

0000-0002-6905-0167

Publications and other outputs

Books

Murphy, D., & Cahill, D.J. (2005). Protein Arrays. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. ISBN: 0-470-84974-6.

Journal Articles

Patel, S., & Murphy, D. [joint first author], Haralambieva, E., Abdulla, Z.A., Wong, K.K., Chen, H., Gould, E., Roncador, G., Hatton, C.S.R., Anderson, A.P., Banham, A.H., Pulford, K. (2014). Increased expression of phosphorylated FADD in anaplastic large cell and other T-cell lymphomas. Biomarker insights 77-84.

Wong, K.K., Gascoyne, D.M., Brown, P.J., Soilleux, E.J., Snell, C., Chen, H., Lyne, L., Lawrie, C.H., Gascoyne, R.D., Pedersen, L.M., Møller, M.B., Pulford, K., Murphy, D., Green, T.M., & Banham, A.H. (2014). Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients. Leukemia, 28(2), 362-372.

Patel, S., Chen, H., Monti, L., Gould, E., Haralambieva, E., Schmid, J., Toomey, D., Woessmann, W., Roncador, G., Hatton, C.S.R., Liggins, A.P., Taramelli, R., Banham, A.H., Acquati, F., Pulford, K. & Murphy, D. [joint last author] (2012). RNASET2–an autoantigen in anaplastic large cell lymphoma identified by protein array analysis. Journal of Proteomics, 75(17), 5279-5292.

Meehan, M., Parthasarathi, L., Moran, N., Jefferies, C., Foley, N., Lazzari, E., Murphy, D., Ryan, J., Chan, T.A. & Stallings, R.L. (2012). Protein Tyrosine Phosphatase Receptor Delta (PTPRD) Acts as a Neuroblastoma Tumor Suppressor by Destabilizing the Aurora Kinase A Oncogene. Molecular Cancer, 11(6).

Arthur, J.F., Shen, Y., Gardiner, E.E., Coleman, L., Murphy, D., Kenny, D., Andrews, R.K., & Berndt, M.C. (2011). TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost, 9(1), 163-72. (Corrigendum: Dec 2011)

Dervan, E.W., Chen, H., Ho, S.L., Brummel, N., Schmid, J., Toomey, D., Haralambova, M., Gould, E., Wallace, D.M., Prehn, J.H., O'Brien, C., & Murphy, D. (2010). Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma. Invest Ophthalmol Vis Sci. 51(6), 2968-75.

Raab, M., Daxecker, H., Edwards, R.J., Treumann, A., Murphy, D., & Moran, D. [joint last author] (2010). Protein interactions with the platelet integrin IIb regulatory motif. Proteomics, 10(15), 2790-800.

Murphy, D., Parker, J., Zhou, M., Karsan, A., Fadlelmola, F., Steidl, C., Gascoyne, R.D., Chen, H., Banerjee, D. (2010). Expression of Cytochrome b5b (CYB5B) in Hodgkin Lymphoma and Aggressive Non-Hodgkin Lymphomas; a Potential Therapeutic Target. Molecular Cancer, 9(1), 14.

Kijanka, G., Hector, S., Kay, E., Murray, F., Cummins, R., Murphy, D., MacCraith, B.D., Prehn, J., Kenny, D. (2010). Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer. Gut, 59(1), 69-78.

Kijanka, G., Barry, R., Cordell, J., Chen, H., Gould, E., Seidlits, S.K., Schmid, J., Morgan, M., Mason, D.Y., Murphy, D. (2009). Defining the molecular target of a ‘paraffin-reactive’ antibody derived from a lymphoma cell line using recombinant protein arrays. Anal Biochem, 395(2), 119-24.

Kijanka, G. & Murphy, D. (2009). Protein arrays as discovery tools in oncology.  Journal of Proteomics, 72(6), 936-44.

Kijanka, G., IpCho, S., Baars, S., Chen, H., Hadley, K., Beveridge, A., Gould, E., & Murphy, D. (2009). Rapid characterization of binding specificity and cross-reactivity of antibodies using recombinant human protein arrays. Journal of Immunological Methods, 340(2), 132-7.

Larkin, D., Treumann, A., Murphy, D., DeChaumont, C., Kiernan, A. & Moran, N. (2008). Compartmentalization regulates the interaction between the platelet integrin alphaIIbbeta3 and ICln. British Journal of Haematology, 144(4), 580-90.

Horn, S., Lueking, A., Murphy, D., Staudt, S., Gutjahr, C., Schulte, K., König, A., Landsberger, M., Lehrach, H., Felix, S.B., Cahill, D.J. (2006). Profiling humoral auto-immune repertoire of dilated cardiomyopathy (DCM) patients and development of a disease-associated protein chip. Proteomics, 6(2), 605-613.

Gutjahr, C., Murphy, D., Lueking, A., Koenig, A., Janitz, M., O’Brien, J., Korn, B., Horn, S., Lehrach, H., & Cahill, D.J. (2005). High-density mouse protein array from a TH1 cell cDNA library. Genomics, 85, 285–296.

Larkin, D., Murphy, D., Reilly, D.F., Cahill, M., Sattler, E., Harriott, P., Cahill, D.J., & Moran, N. (2004). ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation. J Biol Chem. 279(26), 27286-93.

Murphy, D., Detjen, K.M., Welzel, M., Farwig, K., Wiedenmann, B., & Rosewicz, S. (2003). Downregulation of p21waf/cip-1 mediates apotosis of human hepatocellular carcinoma cells in response to interferon-gamma. Exp. Cell. Res. 282(2), 78-89.

Angenendt, P., Glokler, J., Murphy, D., Lehrach, H., & Cahill, D.J. (2002). Toward optimized antibody microarrays: a comparison of current microarray support materials. Anal. Biochem., 309(2), 253-60.

Murphy, D., Detjen, K.M., Welzel, M., Wiedenmann, B., & Rosewicz, S. (2001). Interferon-alpha delays S-phase progression in human hepatocellular carcinoma cells via inhibition of specific cyclin-dependent kinases. Hepatology, 33(2), 346-356.

Plath, T., Detjen, K., Welzel, M., von Marschall, Z., Murphy, D., Schirner, M., Wiedenmann, B., & Rosewicz, S. (2000). A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor. J. Cell Biol., 150(6), 1467-78.

Murphy, D., Seemann, S., Wiese, S., Kirschner, R., Grzeschik, K.H., & Thies, U. (1997). The genomic structure and pattern of expression of the human gene FKHL13 and its mouse homologue hfh-4, members of the HNF-3/fork head gene family. Genomics, 40, 462-469.

Wiese, S., Emmerich, D., Schröder, B., Murphy, D., Grzeschik, K.H., Geurts Kessel, A., & Thies, U. (1997). The novel human HNF-3/fork head like 5 (HFKHL5) gene: chromosomal localisation and expression pattern. DNA and Cell Biology, 16(2), 165-171.

Engel, W., Murphy, D, & Schmid, M. (1996). Are there genetic risks associated with microassisted reproduction? Human Reproduction, 11, 2359-2370.

Aho, H., Schwemmer, M., Tessmann, D., Murphy, D., Mattei, M.G., Engel, W., & Adham, I.M. (1996). Isolation, expression and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP). Genomics, 32, 184-190.

Adham, I.M., Tessmann, D., Soliman, K.A., Murphy, D., Sander, C., & Engel, W. (1996). Cloning, expression, and chromosomal localization of the rat mitochondrial capsule selenoprotein gene (MCS): the reading frame does not contain potential UGA selenocysteine codons. DNA and Cell Biology, 15, 159-166.

Wiese, S., Murphy, D.B., Schlung, A., Burfeind, P., Schmundt, D., Schnülle, V., Mattei, M.G., & Thies, U. (1995). Human brain factor 2 is a member of the fork head gene family and is linked to the human brain factor 1 gene on chromosome 14q. Biochim. Biophys. Acta, 1262, 105-112.

Burkhardt, E., Adham, I.M., Hobohm, U., Murphy, D., Sander, C., & Engel, W. (1994). A human cDNA clone for the Leydig insulin-like peptide (Ley I-L). Human Genetics, 94, 91-94.

Murphy, D.B., Wiese, S., Burfeind, P., Schmundt, D., Mattei, M.G., Schulz-Schaeffer, W., & Thies, U. (1994). Human brain factor 1, a new member of the fork head gene family. Genomics, 21, 551-557.

Research/Professional Interests

Cancer immunology; Autoimmunity; Diagnostics; Biomarkers; Glaucoma; Protein array technology

Professional Activities

Associate Director of Centre for Human Proteomics, RCSI (2005-2009)

Senior Scientist at the Centre for Human Proteomics, RCSI (2002-2005)

Postdoctoral researcher in the “Protein Technology Group”, Max-Planck Institute for Molecular Genetics, Berlin (2001-2002)

Postdoctoral researcher at the Medizinische Klinik mit Schwerpunkt Hepatologie/Gastroenterologie, Charité, Humboldt Universität, Berlin (1998-2001)

Postdoctoral researcher in the Institut für Humangenetik und medizinische Biologie in Halle, Germany (1997-1998)

Research Webpage   

https://www.researchgate.net/profile/Derek_Murphy